Step 1
Evolution of Solutions
Over millions of years, nature evolves mechanisms to treat and prevent disease.
© 2023 Peel Therapeutics | All rights reserved |
Evolution is our platform.
Patients are our purpose.
Evolution has already honed molecules and mechanisms that overcome life-threatening conditions. This occurred over hundreds of millions of years of evolutionary time.
Elephants are resistant to cancer because their genomes contain dozens of copies of a tumor-suppressive gene (for reference, humans only have two copies).
An ancient Chinese tree holds innate, anti-cancer fighting properties that have been shown to effectively treat cancer.
Newborns decrease their inflammatory immune response during the first 48 hours of life, allowing for their microbiomes to colonize without overwhelming inflammation.
At Peel, we translate these awe-inspiring discoveries into medicines for patients with life-threatening diseases. By applying our expertise in evolutionary and molecular biology with a deep understanding of how medicines function in the human body, we dynamically engineer these natural molecules into safe and efficacious treatments for people with devastating cancers and inflammatory diseases.
The Peel R&D engine: Picking up where nature left off
At Peel Therapeutics, our technologies and expertise enable us to determine and deliver on the therapeutic potential of evolutionary outliers that circumvent disease.
Our team seeks the distinct molecules in nature based on the latest academic literature and evolutionary discoveries that exceed what we’ve deemed biologically possible. We are selective in the programs we evaluate and our process includes assessing assets’ molecule’s structure our and its impact on physiology, patients efficacy and safety.
Our multidisciplinary R&D team including biochemistry, molecular biology, evolutionary biology, immunology, cancer research, protein and chemical engineering, drug delivery, clinical trials and medical practice creates a deep understanding of these molecules coupled with our experience in drug delivery enables us to develop these medicines to have a lasting impact for patients.
PEEL ISRAEL AND EARLY DISCOVERY
One of our biggest advantages is our Peel Israel site focused on early discovery and lead candidate development. The scientists of Peel Israel have vast experience in molecular biology, protein engineering, analytical biochemistry, immunology, and drug delivery. The labs are equipped with state-of-the-art instruments and additional high-end equipment is available at the adjacent Technion Israel-Institute of Technology Cores. Peel Israel’s nimble drug development processes redesign nature’s offerings into medicines by improving formulation, stability, and efficacy. Our Peel Israel site acts as the springboard for Peel’s drug pipeline and IND-enabling studies.
Publications and Presentations
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Trent Fowler2023-04-11 14:35:092023-07-07 14:58:52NETosis induction reflects COVID-19 severity and long COVID: insights from a 2-center patient cohort study in Israel
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Trent Fowler2023-02-16 09:13:362023-02-21 09:43:24Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria
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Trent Fowler2023-01-17 09:19:012023-02-13 10:59:04Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial by inhibiting neutrophil extracellular traps
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Emily Hennes
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Emily Hennes2022-08-08 08:00:382023-02-13 09:16:22Of Elephants and Other Mammals: A Comparative Review of Reproductive Tumors and Potential Impact on Conservation
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Emily Hennes
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Emily Hennes2022-07-28 08:00:492023-02-10 07:50:45Neutrophil extracellular trap inhibition improves survival in neonatal mouse infectious peritonitis
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eallison
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eallison2022-03-31 05:00:022022-07-20 13:42:23Neutrophil Extracellular Traps Regulate Ischemic Stroke Brain Injury
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eallison
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eallison2021-08-23 17:30:522022-07-20 13:45:18Elephant Genomes Reveal Accelerated Evolution in Mechanisms Underlying Disease Defenses
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eallison
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eallison2020-09-03 17:32:062022-07-20 13:46:01Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome
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Emily Hennes
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Emily Hennes2020-03-30 08:00:512022-08-09 10:45:17Cancer therapeutics inspired by defense mechanisms in the animal kingdom
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Trent Fowler2023-02-16 09:13:362023-02-21 09:43:24Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria
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Emily Hennes
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Emily Hennes2022-08-08 08:00:382023-02-13 09:16:22Of Elephants and Other Mammals: A Comparative Review of Reproductive Tumors and Potential Impact on Conservation
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eallison
/wp-content/uploads/peel_logo.svg
eallison2021-08-23 17:30:522022-07-20 13:45:18Elephant Genomes Reveal Accelerated Evolution in Mechanisms Underlying Disease Defenses
/wp-content/uploads/peel_logo.svg
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Emily Hennes
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Emily Hennes2020-03-30 08:00:512022-08-09 10:45:17Cancer therapeutics inspired by defense mechanisms in the animal kingdom
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eallison
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eallison2018-03-06 17:48:202022-07-20 13:46:21Accelerated Evolution in Distinctive Species Reveals Candidate Elements for Clinically Relevant Traits, Including Mutation and Cancer Resistance
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eallison
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eallison2015-11-03 17:50:312022-07-20 13:46:42Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans
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Trent Fowler2023-04-11 14:35:092023-07-07 14:58:52NETosis induction reflects COVID-19 severity and long COVID: insights from a 2-center patient cohort study in Israel
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Trent Fowler
/wp-content/uploads/peel_logo.svg
Trent Fowler2023-01-17 09:19:012023-02-13 10:59:04Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial by inhibiting neutrophil extracellular traps
/wp-content/uploads/peel_logo.svg
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Emily Hennes
/wp-content/uploads/peel_logo.svg
Emily Hennes2022-07-28 08:00:492023-02-10 07:50:45Neutrophil extracellular trap inhibition improves survival in neonatal mouse infectious peritonitis
/wp-content/uploads/peel_logo.svg
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eallison
/wp-content/uploads/peel_logo.svg
eallison2022-03-31 05:00:022022-07-20 13:42:23Neutrophil Extracellular Traps Regulate Ischemic Stroke Brain Injury
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eallison
/wp-content/uploads/peel_logo.svg
eallison2020-09-03 17:32:062022-07-20 13:46:01Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome
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eallison
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eallison2016-10-03 17:51:572022-07-20 13:46:32Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation© 2023 Peel Therapeutics | All rights reserved |